标题： 周期性迁移在微图案细胞的物理模型中的研究 显示英文标题

标题： Periodic migration in a physical model of cells on micropatterns

摘要： 我们扩展了一个用于描述爬行的真核细胞形态和动力学的模型，以描述细胞在微图案基质上的行为。 该模型耦合了细胞形态、黏附以及由肌动蛋白和肌球蛋白诱导的主动应力所引发的细胞骨架流动。 我们提出，只有在细胞黏附的位置才会产生推进应力，这导致细胞的有效限制在图案范围内。 与实验结果一致，模拟出的细胞表现出多种行为，包括稳定运动、转向、双足运动以及周期性迁移，在这种迁移中细胞会持续朝一个方向爬行一段时间后反向。 我们表明，周期性运动自然地从细胞极化与细胞形状之间的耦合中产生，通过将模型简化为一维形式，可以对其进行解析理解。 显示英文摘要

摘要： We extend a model for the morphology and dynamics of a crawling eukaryotic cell to describe cells on micropatterned substrates. This model couples cell morphology, adhesion, and cytoskeletal flow in response to active stresses induced by actin and myosin. We propose that protrusive stresses are only generated where the cell adheres, leading to the cell's effective confinement to the pattern. Consistent with experimental results, simulated cells exhibit a broad range of behaviors, including steady motion, turning, bipedal motion, and periodic migration, in which the cell crawls persistently in one direction before reversing periodically. We show that periodic motion emerges naturally from the coupling of cell polarization to cell shape by reducing the model to a simplified one-dimensional form that can be understood analytically.