标题： 超极化13C MRI的数据格式标准化与DICOM集成 显示英文标题

标题： Data Format Standardization and DICOM Integration for Hyperpolarized 13C MRI

摘要： 超极化（HP）13C MRI已被证明是一种有价值的体内代谢测量方法，目前在全球15个研究机构进行人体试验。随着这一领域的发展，采用标准化的数据存储实践非常重要，这将使各研究站点能够有意义地比较数据。在本文中，我们（1）描述了我们认为应存储的数据，并（2）展示了利用医学数字成像和通信（DICOM）标准的管道和方法。这包括提出一组针对HP 13C MRI研究的最小信息集。我们随后展示了这些信息大多数可以如何适配到现有的DICOM属性中，主要是通过“对比剂/注射”模块。我们还展示了利用DICOM进行HP 13C MRI的管道。DICOM是临床医学图像存储最常用的标准，提供了灵活性以适应HP 13C MRI的独特方面，包括HP试剂信息以及光谱和代谢维度。所展示的管道包括为使用各种脉冲序列的人类和动物成像系统的研究创建DICOM对象。我们还展示了一种基于Python的方法，可以高效地修改DICOM对象，以纳入现有管道未捕获的独特的HP 13C MRI信息。此外，我们提出了HP 13C MRI数据存储的最佳实践，这些实践将支持未来多站点试验、研究和该成像技术的技术发展。 显示英文摘要

摘要： Hyperpolarized (HP) 13C MRI has shown promise as a valuable modality for in vivo measurements of metabolism and is currently in human trials at 15 research sites worldwide. With this growth it is important to adopt standardized data storage practices as it will allow sites to meaningfully compare data. In this paper we (1) describe data that we believe should be stored and (2) demonstrate pipelines and methods that utilize the Digital Imaging and Communications in Medicine (DICOM) standard. This includes proposing a set of minimum set of information that is specific to HP 13C MRI studies. We then show where the majority of these can be fit into existing DICOM Attributes, primarily via the "Contrast/Bolus" module. We also demonstrate pipelines for utilizing DICOM for HP 13C MRI. DICOM is the most common standard for clinical medical image storage and provides the flexibility to accommodate the unique aspects of HP 13C MRI, including the HP agent information but also spectroscopic and metabolite dimensions. The pipelines shown include creating DICOM objects for studies on human and animal imaging systems with various pulse sequences. We also show a python-based method to efficiently modify DICOM objects to incorporate the unique HP 13C MRI information that is not captured by existing pipelines. Moreover, we propose best practices for HP 13C MRI data storage that will support future multi-site trials, research studies and technical developments of this imaging technique.