标题： 蜂窝通信中的信使大小最优性 显示英文标题

标题： Messenger size optimality in cellular communications

摘要： 活细胞可能采用优化的信息传递方法，在嘈杂的环境中实现高效的通信。 不出所料，细胞间化学通信的效率取决于分子信使的特性。 证据表明，已被自然选择用于介导细胞间通信的蛋白质来源于狭窄的分子质量范围，但其背后的通信设计原理尚不清楚。 利用一个考虑了化学合成、扩散、分子结合和降解成本的简单物理模型，我们证明存在最优的质量值，可以确保各种类型信号的有效通信。 我们的研究结果为生物通信的设计原则提供了见解，并可用于设计化学通信的仿生系统。 显示英文摘要

摘要： Living cells presumably employ optimized information transfer methods, enabling efficient communication even in noisy environments. As expected, the efficiency of chemical communications between cells depends on the properties of the molecular messenger. Evidence suggests that proteins from narrow ranges of molecular masses have been naturally selected to mediate cellular communications, yet the underlying communication design principles are not understood. Using a simple physical model that considers the cost of chemical synthesis, diffusion, molecular binding, and degradation, we show that optimal mass values exist that ensure efficient communication of various types of signals. Our findings provide insights into the design principles of biological communications and can be used to engineer chemically communicating biomimetic systems.