标题： 化学机械调控的生长组织来自热力学一致框架及其在肿瘤球体生长中的应用 显示英文标题

标题： Chemomechanical regulation of growing tissues from a thermodynamically-consistent framework and its application to tumor spheroid growth

摘要： 人们普遍认识到，细胞与其微环境之间的相互作用，通过机械力和生化信号通路，在正常发育、稳态和疾病进展（如癌症）期间调节细胞行为。然而，复杂组织生长模式的形成机制仍不明确。在此，我们提出一个基于连续介质热力学和生长弹性理论的化学机械调控框架，以预测生长模式。结合弹性能和化学能，我们采用能量变分方法推导出一种新公式，该公式包含能量耗散应力松弛和体积生长速率的生物化学机械调控。我们使用受限环境中肿瘤球体生长的实验数据来验证该模型。我们还研究了模型参数（包括组织重排速率、组织压缩性、机械反馈强度和外部机械刺激）对肿瘤球体生长模式的影响。 显示英文摘要

摘要： It is widely recognized that reciprocal interactions between cells and their microenvironment, via mechanical forces and biochemical signaling pathways, regulate cell behaviors during normal development, homeostasis and disease progression such as cancer. However, it is still not well understood how complex patterns of tissue growth emerge. Here, we propose a framework for the chemomechanical regulation of growth based on thermodynamics of continua and growth-elasticity to predict growth patterns. Combining the elastic and chemical energies, we use an energy variational approach to derive a novel formulation that incorporates an energy-dissipating stress relaxation and biochemomechanical regulation of the volumetric growth rate. We validate the model using experimental data from growth of tumor spheroids in confined environments. We also investigate the influence of model parameters, including tissue rearrangement rate, tissue compressibility, strength of mechanical feedback and external mechanical stimuli, on the growth patterns of tumor spheroids.