标题： 无模板的两亲性微穹顶阵列的精确合成 显示英文标题

标题： Template-free precision synthesis of biphilic microdome arrays

摘要： 两亲性微穹顶阵列在自然界中很常见，但它们的合成对应物却很少。为了弥补这一差距，我们利用凝聚液滴聚合（CDP）来实现其无模板合成。在CDP过程中，单体液滴作为自由基聚合的微反应器。实时监测液滴直径。为了实现凸几何参数的精确预测，我们开发了一个理论框架，该框架结合了几何论证、尺度分析和动力学理论。该模型准确预测了合成后的微穹顶阵列的尺寸，表明这种拓扑结构的合成具有前所未有的精度。为说明其影响，该方法用于制造具有目标尺寸的两亲性微穹顶，以减少生物膜形成病原体铜绿假单胞菌的表面定植。重要的是，这种减少是在一种中等疏水表面上实现的，该表面被认为容易污染，这表明了一种新的材料设计策略，并扩展了合成表面的种类。 显示英文摘要

摘要： Biphilic microdome arrays are ubiquitous in nature, but their synthetic counterparts have been scarce. To bridge that gap, we leverage condensed droplet polymerization (CDP) to enable their template-free synthesis. During CDP, monomer droplets serve as microreactors for free-radical polymerization. The droplet diameter is monitored in real time. To enable the precise prediction of the convex geometric parameters, we develop a theoretical framework that integrates geometric arguments, scaling analysis, and kinetic theories. The model accurately predicts the dimensions of the as-synthesized microdome arrays, pointing to unprecedented precision in the synthesis of such topography. To illustrate its impact, the methodology is used to enable biphilic microdomes with targeted dimensions, for the reduction of surface colonization by a biofilm-forming pathogen, Pseudomonas aeruginosa. Importantly, the reduction is achieved with a moderately hydrophobic surface that has been considered prone to fouling, pointing to a fresh material design strategy and broadened palette of synthetic surfaces.