标题： 关于在孟德尔随机化研究中使用父母寿命作为代理的合理性的一篇笔记 显示英文标题

标题： A Note on The Rationale Behind Using Parental Longevity as a Proxy in Mendelian Randomization Studies

摘要： 在许多队列（如英国生物银行）中，孟德尔随机化研究通常进行，但参与者的长寿数据不足，因为大多数参与者仍然活着。 为了仍然估计对长寿的影响，研究人员越来越常用参与者的“父母达到年龄”，即父母的寿命或当前年龄（这在英国生物银行中通常被收集）作为替代结果。 执行这个巧妙技巧的常见方法似乎基于对其基本假设的扎实理解。 然而，我们在文献中尚未看到这些假设（或它们使识别成为可能的因果效应）被明确陈述 anywhere。 在本说明中，我们填补了这一空白。 显示英文摘要

摘要： In many cohorts (such as the UK Biobank) on which Mendelian Randomization studies are routinely performed, data on participants' longevity is inadequate as the majority of participants are still living. To nevertheless estimate effects on longevity, it is increasingly common for researchers to substitute participants' `parental attained age', i.e. parental lifespan or current age (which is routinely collected in UK Biobank), as a proxy outcome. The common approach to performing this clever trick appears to be based on a solid understanding of its underlying assumptions. However, we have not seen these assumptions (or the causal effects whose identification they enable) clearly stated anywhere in the literature. In this note, we fill that gap.